Cosmetic anti-wrinkle CAS 960608-17-7 Tetrapeptide-21

Tetrapeptide-21 (GEKG-peptide) is a synthetic peptide that repeats a part of a sequence (Gly-Glu-Lys-Gly) of several extracellular matrix (ECM) proteins such as collagens I, II, III, IV, V, elastin, and pro-elastin. It boosts collagen, hyaluronic acid, and fibronectin production by dermal fibroblasts.

It is scientifically proven that fragments of ECM proteins (breakdown product peptides) stimulate regenerative and wound-healing processes in the skin. Tetrapeptide-21 is one of the most effective peptides, which enhances gene expression responsible for collagen production up to  2.5-fold.

In addition, GEKG-peptide increases the expression of genes responsible for the production of other important ECM components, including proteins and glycosaminoglycans (GAGs). Increased hyaluronic acid binds more water molecules, providing adequate hydration, enhanced skin elasticity, and additional volume.

Tetrapeptide-21 is a type of tetrapeptide derived from the skin itself. It has a unique structure and can promote extracellular matrix synthesis, thereby reducing various wrinkles and improving skin aging. Compared to the highly popular matrix peptide in the market, tetrapeptide-21 has a more prominent effect.

Tetrapeptide-21 has shown promise as a skin cream ingredient that can stimulate skin growth and repair. When collagen breaks down, it forms specific tetrapeptides that signal to your skin that it was damaged and needs to make new collagen. So by applying Tetrapeptides topically, your skin believes it has lost collagen recently and needs to make more. It activates collagen production and therefore stimulates dermal filling, repair and renewal mechanisms of the skin.