Cosmetic grade CAS 38083-17-9 Climbazole powder
Products Description
A powerful anti-dandruff active with a long history of successful use. Climbazole provides excellent activity against the main cause of dandruff, Malassezia species. Climbazole is suitable for both leave-on and rinse-off hair care formulations.
Climbazole provides no formation of coloured complexes with metal ions which cause discoloration in formulations. It has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils. It's stable in acid and neutral pH ranges and not hygroscopic (does not absorb water from the air). Climbazole has excellent light, heat and storage stability.
Basic Analysis
| Item of Analysis | Specification | Results |
| Appearance | White crystalline powder | Meet the standard |
| Water | ≤0.5% | 0.12% |
| Melting point | 96-98℃ | 96.8-97.9℃ |
| P-Chlorophenol | ≤0.015 % | 0.003% |
| Assay | ≥99.0% | 99.85% |
Function
- Climbazole is a racemate composed of equimolar amounts of (R)- and (S)-gambaos. The IUPAC name is (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl . -3,3-Dimethylbutane-. 2-one is a topical antifungal agent used to treat fungal skin infections in humans.
- Climbazole can be included in over-the-counter anti-dandruff shampoo formulations and skin treatment compositions. Climbazole can be used to treat dandruff and eczema caused by fungal infections.
- Climbazole mainly uses P450 enzymes to non-competitively block the synthesis of lanosterol 14α-demethylase (also known as fungal CYP51), thereby inhibiting the biosynthesis of ergosterol, which is an important component of plasma fungal plasma membrane. And kill fungal cells.
- Climbazole has a wide range of bactericidal properties and is mainly used in anti-itch/dandruff shampoos and hair care shampoos. It can also be used in antibacterial soap, shower gel, medicinal toothpaste, mouthwash, etc.
Application
Climbazole has a wide range of bactericidal effects and is mainly used in anti-itch, anti-dandruff shampoos and hair care shampoos. It can also be used in high-end detergents such as antibacterial soap, shower gel, medicinal toothpaste, and mouthwash. ..
