High Quality 5000FU/G – 20000FU/G Nattokinase powder

Appearance: Yellow white-off white Powder

Standard: GMP, Kosher, HALAL, ISO9001, HACCP

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Products Description

Nattokinase Extract is an enzyme extracted and purified from a Japanese food called Natto. Natto is a food made from fermented soybeans that has been eaten in Japan for many years. Natto is produced by fermentation by adding the bacterium Bacillus natto, a beneficial bacteria, to boiled soybeans. The resulting nattokinase enzyme is produced when the bacterium acts on the soybeans. While other soy foods contain enzymes, it is only the natto preparation that contains the specific nattokinase enzyme.

Enzymatic Properties

The enzyme is stable in a pH range from 6.0 to 10.0 with the optimum between 7.0 to 9.0. The optimum temperature is 50ºC with a sharp drop over 60ºC.

Activity

One (1) FU unit is defined as the amount of the enzyme which increases the absorbency of the filtrate at 275 nm by 0.01 per minute under the conditions of the assay (JBSL). The acceptance criteria for all enzyme assays is: NLT 85.0% and NMT 115.0% of the declared units of enzyme activity.*

Function & Application

Nattokinase (NK for short), also known as subtilisin, is a serine protease produced by Bacillus subtilisl natto during the fermentation of natto. It has the functions of dissolving thrombus, reducing blood viscosity, improving blood circulation, softening and increasing blood vessel elasticity.

A significant function of nattokinase is to dissolve thrombus. Mimugu F et al. used the clot lysis analysis method to determine the fibrinolytic activity of nattokinase, and compared it with Plasmin, and found that the fibrinolytic activity of nattokinase was 4 times that of Plasmin; MiLsugu. F. When nattokinase was injected intravenously into a chemically induced thrombosis model, it was found that there was obvious thrombolysis, and it showed a higher fibrinolytic ability than plasmin and elastase. The above studies indicate that nattokinase exhibits strong fibrinolytic activity both in vitro and in vivo. Nattokinase can also activate plasminogen in the body, thereby increasing the amount of endogenous plasmin. in addition. After oral administration of nattokinase in healthy people, the following effects appear:

Obviously shorten the dissolution time (ELT) of euglobulin;
Increased fibrinolytic activity in plasma;
The amount of t-PA in plasma has increased. Due to NK's safety, stability and good thrombolytic effect, it may be used as an oral agent for thrombosis treatment.

Basic Analysis

Analysis	Description	Test Method
Activity	NLT20000FU/G	UV
Identity	Nattokinase	FTIR
Moisture	NMT 10%	Ohaus MB-45
Arsenic (As)	< 2 ppm	ICP-MS/AOAC 993.14
Cadmium (Cd)	< 2 ppm	ICP-MS/AOAC 993.14
Lead (Pb)	< 2 ppm	ICP-MS/AOAC 993.14
Mercury (Hg)	< 0.5 ppm	ICP-MS/AOAC 993.14
Microbial Analysis
TPC	<10,000 CFU/g	Soleris / AOAC 990.12
E.coli	Negative/10g	Soleris / AOAC 991.14
Entero	<100 CFU/g	AOAC 2003.01
Salmonella	Negative/25g	BAM Ch. 5 / AOAC 2011.03
Yeast	<1,000 CFU/g	Soleris / AOAC 997.02
Mold	<1,000 CFU/g	Soleris / AOAC 997.02
Coliforms	<100 CFU/g	Soleris / AOAC 991.14

Gmo statement

We hereby declare that, to the best of our knowledge, this product was not produced from or with GMO plant material.

Ingredient statement

Statement Option #1: Pure Single Ingredient
This 100% single ingredient does not contain or use any additives, preservatives, carriers and/or processing aids in its manufacturing process.
Statement Option #2: Multiple Ingredients
Must include all/any additional sub ingredients contained in and/or used in its manufacturing process.

Gluten free statement

We hereby declare that, to the best of our knowledge, this product is gluten-free and was not manufactured with any ingredients containing gluten.

(Bse)/ (Tse) Statement

We hereby confirm that, to the best of our knowledge, this product is free of BSE/TSE.

Cruelty-free statement

We hereby declare that, to the best of our knowledge, this product has not been tested on animals.

Kosher statement

We hereby confirm that this product has been certified to Kosher standards.

Vegan Statement

We hereby confirm that this product has been certified to Vegan standards.

Food Allergen Information

ALLERGENS	PRESENCE	ABSENCE	PROCESS COMMENT
Milk or milk derivatives	No	Yes	No
Egg or egg derivatives	No	Yes	No
Fish or fish derivatives	No	Yes	No
Shellfish, crustaceans, mollusks & their derivatives	No	Yes	No
Peanuts or peanut derivatives	No	Yes	No
Tree nuts or their derivatives	No	Yes	No
Soy or soy derivatives	No	Yes	No
Wheat or wheat derivatives	No	Yes	No