Hot Selling Palmitoyl Pentapeptide-4 Cosmetic Peptide CAS 214047-00-4
Product Description
Palmitoyl pentapeptide-4, also known as palmitoyl pentapeptide-3/M-based peptide, is composed of five amino acid small molecular peptides and palmitoyl, and the amino acid sequence is lysine - threonine - threonine - lysine - serine (KTTKS). Palmitoyl pentapeptide-4 is a synthetic short peptide derived from Collagen I fragments. It was launched on the market around 2000 and is one of the earliest and most widely used peptides. As the pioneer of skin care with polypeptide ingredients, palmitoyl pentapeptide-4 has great influence on the cosmetics raw material market. Currently, the palmitoyl series polypeptides launched on the market are mostly developed based on palmitoyl pentapeptide-4. It has good anti-aging and anti-wrinkle effects. The addition amount in cosmetics is 0.01%
Basic Analysis
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Item
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Specification
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Result
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Test Methods
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Appearance
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white powder
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Conforms
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Organoleptic
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Odor & taste
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Characteristic
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Conforms
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Organoleptic
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Mesh size
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Through 80 mesh
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Conforms
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80 mesh screen
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Assay
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≥98.0%
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99.23%
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HPLC
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Loss on Drying
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≤5.00%
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2.85%
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Drying Method
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Ash
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≤5.00%
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0.29%
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Ashing Method
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Heavy metals
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|||
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Total Heavy Metals
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≤10ppm
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Conforms
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|
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Arsenic
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≤1ppm
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Conforms
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GF AAS
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Lead
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≤2ppm
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Conforms
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AFS
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Cadmium
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≤1ppm
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Conforms
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AFS
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Hygrargyrum
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≤0.1ppm
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Conforms
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AFS
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Residual Solvent
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Meet the requirements
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Conforms
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SOP/SA/SOP/SUM/304
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Pesticide Residue
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Meet the requirements
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Not detected
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SOP/SA/SOP/SUM/304
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Microbiological Tests
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|||
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Total Plate Count
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≤3000cfu/g
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Conforms
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Bacterial culture
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Total Yeast & Mold
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≤300cfu/g
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Conforms
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Bacterial culture
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E.Coli
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Negative
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Conforms
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Bacterial culture
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Salmonella
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Negative
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Conforms
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Bacterial culture
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Staphylococcus
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Negative
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Conforms
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Bacterial culture
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Function
- Promote Collagen Synthesis
Palmitoyl Pentapeptide-4 operates as a classic cellular messenger (Matrikine). It structurally mimics the natural break-down fragments of human collagen, triggering a feedback loop that tricks fibroblasts into an "overdrive" cellular repair state. Clinical and in vitro data indicate that it dramatically upregulates the production of Collagen Type I, Type III, and Type IV.
- Extracellular Matrix (ECM) Repair
Beyond collagen, it promotes the synthesis of fibronectin, glycosaminoglycans (GAGs), and hyaluronic acid—the structural building blocks that keep skin plump and hydrated.
- Precision Therapy for Static & Structural Wrinkles
Unlike neurotransmitter-inhibiting peptides (such as Acetyl Hexapeptide-8) which target dynamic expression lines, Palmitoyl Pentapeptide-4 specializes in repairing static, deep-set wrinkles (e.g., prominent nasolabial folds, deep neck lines, and stubborn under-eye furrows) caused by chronological aging and UV degradation. It literally re-architects the skin from underneath to flatten dermal depressions.
- Non-Invasive Anti-Aging Safe for Fragile Skin Barriers
Traditional cellular-turnover drivers like Retinoids or AHAs routinely compromise the skin’s stratum corneum, invoking redness, purging, and photo-sensitivity. Palmitoyl Pentapeptide-4 achieves exceptional anti-wrinkle efficacy via internal signaling without causing micro-tears or epidermal shedding. It is completely photostable (suitable for AM/PM use) and remains the premier choice for sensitive skin or post-treatment formulations.
Application
Because of its exceptional stability, low operational dosage requirements, and excellent compatibility with other actives, Palmitoyl Pentapeptide-4 is incredibly versatile. It is a star ingredient across multiple product formats.
Palmitoyl pentapeptide-4 is used as an antioxidant, skin care products, moisturizers or other preparations in cosmetics and skin care products. Providing anti wrinkle, anti-aging, anti-oxidation, skin firming, moisturizing and other effects in beauty and care products (such as gel, lotion, AM/PM cream, eye cream, facial mask, etc.), and apply them to face, body, neck, hand and eye skin care products.
- High-Potency Regenerative Serums & Emulsions
✅ Market Position: Clean-label, premium anti-aging treatment lines.
✅ Synergistic Blends: We recommend pairing it with Acetyl Hexapeptide-8 or Recombinant Collagen for a complete "Relax + Rebuild" mechanism.
- Targeted Orbital Zone & Advanced Eye Creams
✅ Market Position: Clinical eye-care targeting fine lines, micro-sagging, and structural hollows.
✅ Synergistic Blends: Formulated alongside Caffeine or Palmitoyl Tetrapeptide-7 to concurrently stimulate microcirculation and collagen matrix density, targeting puffiness, dark circles, and crow's feet simultaneously.
- Medical Esthetic Post-Procedure & Barrier-Restorative Creams
✅ Market Position: Post-laser, post-microneedling, or clinical peeling recovery lines designed to accelerate dermal healing.
✅ Synergistic Blends: Combined with Ceramides, Madecassoside, and Multi-weight Hyaluronic Acid Complex inside ultra-clean, minimalist bases to heal skin barriers while preserving inner anti-aging activity.
- Nano-Infused Ampoules & High-Performance Bio-Cellulose Masks
✅ Market Position: Single-dose flash treatments for immediate firming and plumping results.
✅ Formulation Technology: Utilizing Nano-Liposome Delivery Technology to augment transdermal absorption. Ideal for clinical skincare brands, high-end spa ranges, or flash-acting freeze-dried mask concepts.
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