water soluble Totarol Cosmetic Ingredients CAS 511-15-9 Totarol powder
Products Description
Totarol is a naturally produced diterpene that is bioactive. It was first isolated by McDowell and Easterfield from the heartwood of Podocarpus totara, a conifer tree found in New Zealand. Podocarpus totara was investigated for unique molecules due to the tree's increased resistance to rotting.Recent studies have confirmed totarol's unique antimicrobial and therapeutic properties. Consequently, totarol is a candidate for a new source of drugs and has been the goal of numerous syntheses.
characteristic
- Antioxidant activity: It has strong antioxidant capacity and can effectively eliminate free radicals in the body, such as hydroxyl radicals, superoxide anion radicals, etc., protecting cells from oxidative damage. Its antioxidant effect is superior to the common antioxidant vitamin E.
- Antibacterial activity: It has significant inhibitory effects on various bacteria, including Staphylococcus aureus, Escherichia coli, Propionibacterium acnes, etc. It can damage the integrity of bacterial cell membranes and interfere with bacterial metabolic processes.
- Anti inflammatory: By inhibiting the release of inflammatory factors such as interleukin-1 β, tumor necrosis factor - α, etc., it reduces inflammation and has a certain relieving effect on skin inflammation, arthritis, etc.
BASIC ANALYSIS
| Item | Specification | Result |
| Assay(BY- HPLC)content | ≥80% | 82.42% |
| Physical＆chemical Control | ||
| Appearance | Yellow-orange powder | Conforms |
| Loss on drying | ≤5.0% | 1.99% |
| Residue on ignition | ≤2.0% | 0.06% |
| Lead | ≤10ppm | Conforms |
| Arsenic | ≤2ppm | Conforms |
| Mercury | ≤1ppm | Conforms |
| Cadmium | ≤5ppm | Conforms |
| Microbiological control | ||
| Total of bacterium | ≤100CFU/g | Conforms |
| Yeast＆Mold | ≤10CFU/g | Conforms |
| Thermotolerant coliform bacteria | Negative | Negative |
| Staphylococcus aureus | Negative | Negative |
| Pseudomonas aeruginosa | Negative | Negative |
Function
Antibacterial and anti-inflammatory
- Inhibition of Propionibacterium acnes: Propionibacterium acnes is one of the main bacteria causing acne, and Totarol has a significant inhibitory effect on it, which can reduce the occurrence of acne and inflammatory reactions, making the skin fresher and cleaner. For oily and acne prone skin, it helps control oil secretion, reduce acne production and redness.
- Preventing skin infections: It also has an inhibitory effect on common skin pathogens such as Staphylococcus aureus and Escherichia coli, and can prevent skin inflammation caused by these bacterial infections, such as folliculitis and furuncles, and maintain the health of the skin.
Antioxidant
- Clearing free radicals: Free radicals are one of the important factors leading to skin aging. Totarol has strong antioxidant capacity and can effectively eliminate free radicals in the body, such as hydroxyl radicals, superoxide anion radicals, etc., reducing the damage of free radicals to skin cells and delaying the process of skin aging.
- Reduce wrinkles and fine lines: Through antioxidant effects, protect collagen and elastic fibers in the skin, maintain skin elasticity and firmness, reduce the appearance of wrinkles and fine lines, make the skin smoother and more delicate, and present a youthful state.
Soothing repair
- Relieve skin inflammation: For sensitive skin or skin that is prone to inflammatory reactions, Totarol can inhibit the release of inflammatory factors such as interleukin-1 β, tumor necrosis factor - α, etc., reducing discomfort symptoms such as redness, itching, and stinging, and playing a soothing and repairing role.
- Enhancing skin barrier function: helps maintain the integrity of the skin barrier, enhances the skin's self-protection ability, and enables the skin to better resist external environmental stimuli such as ultraviolet radiation, pollutants, etc., reducing the occurrence of skin allergies and sensitivities.
Collaborative efficiency enhancement
- Synergistic with Vitamin C: Vitamin C mainly focuses on whitening and antioxidant properties, while Totarol's antibacterial and anti-inflammatory effects can complement it to jointly resist the damage of free radicals to the skin, while inhibiting pigmentation caused by inflammation, making the skin brighter and whiter.
- Synergistic with hyaluronic acid: Hyaluronic acid has moisturizing effects. When used together with hyaluronic acid, Totarol not only replenishes moisture to the skin, but also prevents water loss caused by bacterial growth and inflammatory reactions, keeping the skin hydrated and plump.
Application
- Pharmaceutical field: research has found that Totarol has potential application value in the treatment of infectious diseases and inflammatory diseases, and is expected to be developed into new drugs, and can also be used as drug excipients to enhance drug stability and efficacy.
- Skin care products: because of its antioxidant and antibacterial properties, it is widely used in skin care products, such as face cream, essence, facial mask, etc., which can delay skin aging, improve skin inflammation, and prevent acne.
- In the field of oral care: added to toothpaste, mouthwash and other products, it can inhibit the growth of oral bacteria and prevent oral diseases such as dental caries and periodontitis.
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